CloseHelpPrint
Kies de Nederlandse taal
Course module: 8QA04
8QA04
DBL Medicine (1 + 1 is not 2)
Course info
Course module8QA04
Credits (ECTS)5
Category1 (Introductory)
Course typeBachelor College
Language of instructionDutch
Offered byEindhoven University of Technology; Biomedical Engineering; Biomedical Chemistry;
Is part of-
Contact persondr.ir. M.H.P. van Genderen
Telephone2792
E-mailm.h.p.v.genderen@tue.nl
Lecturer(s)
Contactperson for the course
dr.ir. M.H.P. van Genderen
Other course modules lecturer
Responsible lecturer
dr.ir. M.H.P. van Genderen
Other course modules lecturer
Co-ordinator
ir. R. van der Heijden
Other course modules lecturer
Lecturer
ir. R. van der Heijden
Other course modules lecturer
Academic year2017
Period
2  (13/11/2017 to 04/02/2018)
Starting block
2
TimeslotD: D - We 5-8, Th 9-10, Fr 1-4
E: E - Mo 9-10, Tu 5-8, Th 1-4
Course mode
Fulltime
Remarks-
Registration openfrom 15/06/2017 up to and including 15/10/2017
Application procedureYou apply via OSIRIS Student
Explanation-
Registration using OSIRISYes
Registration open for students from other department(s)No
Pre-registrationNo
Waiting listYes
Number of insufficient tests-
Number of groups of preference0
Learning objectives
After passing the course, the student has insight in:
  1. Written communication and can apply this when writing a self-study and a report.
  2. Collaboration with other students and can apply this when together creating a joint groups product.
  3. Reflection on own work and the work of others in the form of peer review and processing intermediate feedback on a draft product.
  4. Making time schedules when planning to work towards a predefined deadline.
  5. Verbal presentations and applies this during meetings and group work.
  6. Ways of searching for and dealing with scientific information by means of individually looking up information and using this information for the final product.
After passing the course, the student is able to:
  1. Apply and integrate the acquired knowledge on farmacokinetics, by means of theory, model (Simulink) and experiments to address the problem statement.
  2. Show insight in the ethical aspects of working with test subjects by describing and discussing these aspects.
Content
Due to a viral infection, Erik suffers from muscle ache. Therefore, his physician has prescribed an analgesic drug: Erik is allowed to take one tablet each time, with a maximum of 6 tablets per day. Indeed Erik notices considerable relieve of his pain after taking his medication. However, this relieve is short-lasting: every 5 hours Erik needs to take a new tablet in order to avoid experiencing pain again. Erik's friend Fred suggests to take two tablets at once instead of one tablet in order to double the duration of action of the drug, so that Erik would have no pain for 10 hours. Erik however raises some doubt about this and asks himself the question whether the duration of action of drugs is a simply a matter of summing the dosages. Fred however argues that it takes one hour for each glass of beer before the alcohol in the blood has disappeared. Erik decides to closely monitor the time it takes before experiencing pain after having swallowed 2 tablets. Unexpectedly, the pain reoccurs already after 7 hours.
Erik wonders: "Why does the pain reoccur after 7 instead of 10 hours? How is it possible that drugs seem to obey different rules than alcohol?" Intuitively Erik suspects a relation between the amount of drug in the blood and its action. Using a spreadsheet, he tries to construct concentration-time profiles for the drug in blood. Although he is able to obtain curves and although these curves offer an explanation for the dose-doubling enigma he is not sure whether the curves are realistic......
During their weekly evening out Erik discusses his dose doubling experiences and attempts to construct drug concentration-time curves with Fred. Late at night, on their way home Fred suggests that it would be a great idea if they would construct a computer program that predicts the amount of alcohol in their blood. "Such program would notify us whether or not we are allowed to cycle and could be put on our cell phones. Surely, this could be marketed". "Well" Erik says, "I even think that by using a simple trick and virtually no additional effort, we might even use such an alcohol computer program to simulate the type of concentration-time profiles that are observed for a wide variety of drugs like e.g. paracetamol. This would allow us to explain why the duration of action of paracetamol is not twice as long if its dose is doubled."
Next day Fred wakes up hungry and with a splitting headache. What should he do: First take a paracetamol and have breakfast one hour later or should he first have his breakfast and then take this medication?


 
Entrance requirements
You have to be registered for one of the following degree programmes:
- Biomedical Engineering
- Medical Sciences and Engineering
Entrance requirements tests
-
Assumed previous knowledge
-
Previous knowledge can be gained by
-
Resources for self study
-
Short promotional description of the course
Wanneer je een pijnstiller moet nemen, en wat het effect daarvan op je lichaam is weten de meesten mensen wel. Maar wat doet je lichaam vervolgens met deze pijnstiller? En is het effect van het innemen van één tablet wel hetzelfde voor iedereen? In deze casus leer je door middel van theorie, experiment en een model de vraag beantwoorden of het innemen van twee tabletten pijnstillers je ook twee keer zo lang van je hoofdpijn af helpt. Dus is in dit geval 1+1 nu wel of niet 2.
Bachelor College or Graduate School
Bachelor College
Required materials
-
Recommended materials
Case information on Canvas.
Instructional modes
DBL-group meeting

General
-

Remark
-
Lecture

General
-

Remark
-
Lecture - Ethics

General
-

Remark
-
Training

General
-

Remark
-
Tests
Peer review
Test weight25
Minimum grade6
Test typeInterim examination
Number of opportunities1
OpportunitiesBlock 2
Test duration in minutes-

Assessment
-

Remark
-

Individual mark
Test weight25
Minimum grade6
Test typeInterim examination
Number of opportunities1
OpportunitiesBlock 2
Test duration in minutes-

Assessment
-

Remark
-

Final report
Test weight50
Minimum grade6
Test typeFinal examination
Number of opportunities1
OpportunitiesBlock 2
Test duration in minutes-

Assessment
-

Remark
-

CloseHelpPrint
Kies de Nederlandse taal