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Course module: 8QB10
8QB10
DBL Entering the lab
Course info
Course module8QB10
Credits (ECTS)5
Category2 (Deepening)
Course typeBachelor College
Language of instructionDutch
Offered byEindhoven University of Technology; Biomedical Engineering; Protein Engineering;
Is part of
Medical Sciences and Engineering
Contact persondr. C. Ottmann
Telephone2835
E-mailc.ottmann@tue.nl
Lecturer(s)
PreviousNext 2
Lecturer
prof.dr.ir. L. Brunsveld
Other course modules lecturer
Lecturer
prof.dr. P.Y.W. Dankers
Other course modules lecturer
Co-ordinator
ir. R. van der Heijden
Other course modules lecturer
Lecturer
prof.dr. M. Merkx
Other course modules lecturer
Lecturer
dr. L.G. Milroy
Other course modules lecturer
Academic year2017
Period
3  (05/02/2018 to 22/04/2018)
Starting block
3
TimeslotC: C - Tu 1-4, Fr 5-8, Fr 9-10
E: E - Mo 9-10, Tu 5-8, Th 1-4
Course mode
Fulltime
Remarks-
Registration openfrom 15/11/2017 up to and including 07/01/2018
Application procedureYou apply via OSIRIS Student
Explanation-
Registration using OSIRISYes
Registration open for students from other department(s)No
Pre-registrationNo
Waiting listYes
Number of insufficient tests-
Number of groups of preference0
Learning objectives
After passing the course, the student has insight in:
  1. Written communication and can apply this when writing a self-study and a report.
  2. Collaboration with other students and can apply this when together creating a joint groups product.
  3. Reflection on own work and the work of others in the form of peer review and processing intermediate feedback on a draft product.
  4. Making time schedules when planning to work towards a predefined deadline.
  5. Verbal presentations and applies this during meetings and group work.
  6. Ways of searching for and dealing with scientific information by means of individually looking up information and using this information for the final product.
After passing the course, the student is able to:
  1. Apply laboratory experimental and analytical work in one of the laboratories of the department when formulating and working out a simple research assignment and hypothesis and critically reviewing these components and the results.
Content
Finally, the time is there. You will get to work in the lab.
During this OGO, groups of ±6 students will work on a challenging research project in the field of chemical biology. The research activities will be performed in laboratories dedicated to (organic) chemistry and bioanalysis. Your aim is to develop a new medicine to treat high blood pressure; the most prevalent chronic syndrome in Western countries that is closely related to life-threatening diseases such as heart and kidney failure. The Angiotensin I converting enzyme (ACE) plays a key role in blood pressure regulation. Your research will focus on the design of small peptide-based medicine that have the ability to inhibit ACE. As a group you will formulate a research proposal. Based on this proposal, each group member will work on his/her own ACE-inhibitor design (week 1 & 2), synthesize the designed peptide (week 3), characterize the synthesis product using a diversity of spectroscopic analysis techniques (week 4), and finally test the ACE inhibitory effect of the peptide in a bioanalytical assay (week 5 & 6). The OGO will conclude with a scientific seminar during which each group present its best and most interesting results. In addition, each student compiles an analysis record and writes a short report.
Entrance requirements
You have to be registered for one of the following degree programmes:
- Biomedical Engineering
- Medical Sciences and Engineering
Or at least one of the following course modules must be completed:
- Programming and genomics (8CA10)
- Bio informatics (8CA00)
- Genomics and computational biology (8CB00)
Entrance requirements tests
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Assumed previous knowledge
• 8SA00 - Introduction Organic Chemistry
• 8RA00 - Biochemistry
Previous knowledge can be gained by
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Resources for self study
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Required materials
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Recommended materials
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Instructional modes
DBL-group meeting

General
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Remark
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Lecture

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Training

General
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Tests
Individual mark
Test weight50
Minimum grade6
Test typeFinal examination
Number of opportunities1
OpportunitiesBlock 3
Test duration in minutes-

Assessment
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Remark
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Group mark
Test weight35
Minimum grade6
Test typeInterim examination
Number of opportunities1
OpportunitiesBlock 3
Test duration in minutes-

Assessment
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Remark
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Research proposal
Test weight15
Minimum grade6
Test typeInterim examination
Number of opportunities1
OpportunitiesBlock 3
Test duration in minutes-

Assessment
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Remark
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Training Matlab
Test weight0
Minimum grade-
Test typeInterim examination
Number of opportunities1
OpportunitiesBlock 3
Test duration in minutes-

Assessment
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Remark
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