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Course module: 8RA00
8RA00
Biochemistry
Course info
Course module8RA00
Credits (ECTS)5
Category1 (Introductory)
Course typeBachelor College
Language of instructionDutch
Offered byEindhoven University of Technology; Biomedical Engineering; Chemical Biology;
Is part of
Biomedical Engineering
Chemical Engineering and Chemistry
Coherent package - Chemical biology
Coherent package - Molecular Systems and Materials Chemistry
Pre-master program MCE Molecular Syst.& Materials Chemistry
Medical Sciences and Engineering
Contact personprof.dr.ir. J.C.M. van Hest
Telephone3515
E-mailj.c.m.v.hest@tue.nl
Lecturer(s)
Contactperson for the course
prof.dr.ir. J.C.M. van Hest
Other course modules lecturer
Responsible lecturer
prof.dr.ir. J.C.M. van Hest
Other course modules lecturer
Co-lecturer
prof.dr. M. Merkx
Other course modules lecturer
Academic year2017
Period
4  (23/04/2018 to 08/07/2018)
Starting block
4
TimeslotB: B - Mo 5-8, Tu 9-10, We 1-4
C: C - Tu 1-4, Fr 5-8, Fr 9-10
Course mode
Fulltime
Remarks-
Registration openfrom 15/11/2017 up to and including 25/03/2018
Application procedureYou apply via OSIRIS Student
Explanation-
Registration using OSIRISYes
Registration open for students from other department(s)Yes
Pre-registrationNo
Waiting listNo
Number of insufficient tests-
Number of groups of preference0
Learning objectives
After passing the course, the student has knowledge of:
  1. Molecular sciences and biochemistry and can use biomolecular structures and biochemical processes
  2. The constitution and structure of proteins and can explain the structure and function of bio(macro)molecules
  3. Methods for protein purification and characterization and can explain, apply and interpret the results of purification and analysis techniques
  4. Enzyme function and kinetics and can use Michaelis-Menten kinetics, design an active site of an enzyme and explain the molecular basis of enzyme action.
  5. The constitution and structure of nucleic acids and can draw and recognize nucleic acids, describe methods for the analysis of nucleic acids and describe the processes for DNA to protein.
  6. The methods and principles of recombinant DNA techniques and can explain, apply and interpret the results of purification and analysis techniques.
  7. The constitution and structure of lipids and biomembranes and principles of membrane transport and can describe and relate structure and function of biomembranes, the structure of lipids and the functioning of membrane proteins.
Content
The students know:
  • Relation between organic chemistry and biochemistry
  • Constitution and structure of proteins
  • Methods for the purification of proteins
  • Principles of enzyme function and kinetics
  • Constitution and structure of nucleic acids Methods for the analysis of nucleic acids Processes of replication transcription and translation
  • Principles of recombinant DNA techniques
  • Constitution and structure of lipids and biomembranes
  • Principles of membrane transport

The students can:
  • Apply knowledge of organic chemistry in biochemistry
  • Explain how the structure of biomacromlecules arises
  • Explain the relation between structure and function of bio(macro)molecules
  • Interpret the results of purification and analysis techniques
  • Apply Michaelis-Menten kinetics
  • Design an active site of an enzyme
  • Describe the processes from DNA to protein
  • Describe recombinant DNA techniques
  • Relate the properties of biomembranes to the structure of lipids
     
Entrance requirements
Entrance requirements tests
-
Assumed previous knowledge
• 8SA00 - Introduction Organic Chemistry (recommended)
Previous knowledge can be gained by
-
Resources for self study
-
Short promotional description of the course
De basis voor de moleculaire life sciences. Dit vak laat je kennis maken met de moleculaire principes van de biomedische wetenschappen. Ontwikkeling van medicijnen, tissue engineering, ziektes, kun je alleen goed doorgronden en oplossen als je weet wat de moleculaire oorzaak is. De college's worden doorlopend geïllustreerd met voorbeelden over drug discovery, biomaterialen en de moleculaire oorzaak van ziektes.
Short promotional description of the course
The basis for the molecular life sciences. This course introduces you to the molecular principles of the biomedical sciences. The development of drugs, tissue engineering, diseases: you can only understand them thoroughly and find solutions if you understand the molecular causes. The classes are illustrated with examples about drug discovery, biomaterials and the molecular causes of diseases.
Required materials
Stryer, Biochemistry, 8th edition
Recommended materials
-
Instructional modes
Guided selfstudy

General
The lectures and independent learning under supervision will take place in time slot C;

Remark
-
Lecture

General
The lectures and independent learning under supervision will take place in time slot C;

Remark
-
Practical work

General
The two practical experiments each require one day element (morning or afternoon). The exact dates for this will be announced at the beginning of the 4th quarter. There can be no correspondence about this matter.

Remark
-
Tests
Experiment 1
Test weight15
Minimum grade-
Test typeInterim examination
Number of opportunities1
OpportunitiesBlock 4
Test duration in minutes-

Assessment
-

Remark
-

Assignment 2
Test weight15
Minimum grade-
Test typeInterim examination
Number of opportunities1
OpportunitiesBlock 4
Test duration in minutes-

Assessment
-

Remark
-

Final examination
Test weight70
Minimum grade5
Test typeFinal examination
Number of opportunities2
OpportunitiesBlock 4, Block I
Test duration in minutes-

Assessment
-

Remark
-

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