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Course module: 8RB20
8RB20
Chemical biology
Course info
Course module8RB20
Credits (ECTS)5
Category3 (Advanced)
Course typeBachelor College
Language of instructionDutch
Offered byEindhoven University of Technology; Biomedical Engineering; Chemical Biology;
Is part of
Biomedical Engineering
Pre-master program Biomedical Engineering
Coherent package - Chemical biology
Coherent package - Chemical biology
Medical Sciences and Engineering
Contact persondr. C. Ottmann
Telephone2835
E-mailc.ottmann@tue.nl
Lecturer(s)
PreviousNext 4
Co-lecturer
prof.dr.ir. L. Brunsveld
Other course modules lecturer
Co-lecturer
prof.dr. P.Y.W. Dankers
Other course modules lecturer
Co-lecturer
dr.ir. T.F.A. de Greef
Other course modules lecturer
Co-lecturer
prof.dr. E.W. Meijer
Other course modules lecturer
Co-lecturer
prof.dr. M. Merkx
Other course modules lecturer
Academic year2017
Period
4  (23/04/2018 to 08/07/2018)
Starting block
4
TimeslotA: A - Mo 1-4, We 9-10, Th 5-8
Course mode
Fulltime
Remarks-
Registration openfrom 15/11/2017 up to and including 25/03/2018
Application procedureYou apply via OSIRIS Student
Explanation-
Registration using OSIRISYes
Registration open for students from other department(s)Yes
Pre-registrationNo
Waiting listNo
Number of insufficient tests-
Number of groups of preference0
Learning objectives
After passing the course, the student has insight in:
  1. Different methods of protein structure elucidation (NMR, Xray), protein domain organization, protein engineering, peptide recognition, peptide synthesis, protein-ligand interactions and can describe them and their use in chemical biology.
  2. Chemical biology compounds and can describe them and explain how cell surface and nuclear receptors can be analyzed by these compounds.
  3. The concepts of microfluidic devices and macroscopic assay and can describe the advantages of microfluidic devices compared to macroscopic assays and explain methods of preparing these devices.
  4. The concept of Activity-Based Protein Profiling (ABPP), the ‘bump-and-hole’ approach and can explain, describe and design specific enzyme-ligand pairs and different methods of protein labelling.
  5. Different assay techniques and can describe and reflect on the different means of identifying bioactive molecules.
  6. The concepts of DNA sequencing and RNA technologies and can discuss technological advances in DNA sequencing and the use of RNA technologies to modulate biological systems.
Content
  • Small-molecule modulation of protein function
  • Protein engineering
  • Chemical genomics
  • Expressed protein ligation and native chemical ligation
  • In vivo protein labelling
  • Activity-based protein profiling
  • Phage display and yeast hybrids
Entrance requirements
Entrance requirements tests
-
Assumed previous knowledge
-
Previous knowledge can be gained by
-
Resources for self study
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Short promotional description of the course
Dit vak bevat een overzicht van de ontwikkeling en toepassing van chemische technieken, methodologie en moleculen voor de studie van biologische systemen (eiwitten, nucleïnezuren, cellen, organismen). Het vak integreert de opgedane chemische kennis met die van de moleculaire en medische biologie. Het vak wordt rijkelijk geïllustreerd met voorbeelden uit lopende onderzoek in het gebied en van de faculteit.
Short promotional description of the course
This course deals with an overview of the developments and application of chemical techniques, methodology and molecules for the study of biological systems (proteins, nucleic acids, cells, organisms). The course integrates the acquired chemical knowledge with that of the molecular and medical biology. The course will be richly illustrated using examples of recent research in the area and from the department.
Required materials
-
Recommended materials
"Introduction to Bioorganic Chemistry and Chemical Biology"
Instructional modes
Guided selfstudy

General
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Remark
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Lecture

General
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Remark
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Tests
Written examination
Test weight100
Minimum grade-
Test typeFinal examination
Number of opportunities2
OpportunitiesBlock 4, Block I
Test duration in minutes-

Assessment
-

Remark
-

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