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Course module: 8SM20
8SM20
Biomaterials
Course info
Course module8SM20
Credits (ECTS)5
Category-
Course typeGraduate School
Language of instructionEnglish
Offered byEindhoven University of Technology; Biomedical Engineering; Biomedical Chemistry;
Is part of-
Contact personprof.dr. P.Y.W. Dankers
Telephone5451
E-mailP.Y.W.Dankers@tue.nl
Lecturer(s)
Co-lecturer
prof.dr. J.J.C. Arts
Other course modules lecturer
Contactperson for the course
prof.dr. P.Y.W. Dankers
Other course modules lecturer
Responsible lecturer
prof.dr. P.Y.W. Dankers
Other course modules lecturer
Co-lecturer
dr. S. Hofmann Boss
Other course modules lecturer
Academic year2017
Period
GS3  (05/02/2018 to 22/04/2018)
Starting block
GS3
TimeslotA: A - Mo 1-4, We 9-10, Th 5-8
Course mode
Fulltime
Remarks-
Registration openfrom 15/11/2017 up to and including 07/01/2018
Application procedureYou apply via OSIRIS Student
Explanation-
Registration using OSIRISYes
Registration open for students from other department(s)Yes
Pre-registrationNo
Waiting listNo
Number of insufficient tests-
Number of groups of preference0
Learning objectives
The student is able to:
  • define the terms ‘biomaterials’ and ‘materiomics’.
  • understand the difference between different kind of biomaterials, such as hydrogels and thermoplastic elastomers.
  • name and understand the different biomaterials properties that are important in the field of regenerative medicine, but also more in general as an implant.
  • understand how biomaterials properties can be regulated using various chemical structures.
  • name and understand techniques that can be used to study biomaterials properties, both bulk and surface properties.
  • name various morphologies/scaffold types in which biomaterials can be applied.
  • describe different processing techniques to make different biomaterial scaffolds/morphologies.
  • explain ‘supramolecular chemistry’ and ‘supramolecular polymers’.
  • name and understand different supramolecular biomaterials.
  • describe the order of reactions that happen after implantation of a biomaterial in vivo.
  • understand different kind of biomaterials (e.g. ceramics, metals, polymers, biopolymers).
  • understand the difference between bulk and surface erosion.
  • explain the properties of anti-fouling biomaterials.
  • understand the process of protein adsorption on biomaterials.
  • explain the process of biofilm formation.


    In this course you will be introduced to the field of Biomaterials Science. You will learn what happens when biomaterials (i.e. foreign bodies) are brought into contact with cells, tissues and organs. The reaction that is elicited by these biomaterials in vivo is called the tissue response / foreign body response.
  • Content
    Interactions between (synthetic) biomaterials and tissues play a key role when a part of the body is replaced by an implant. At the surface of these implants (e.g. stents, sutures, hip prostheses, heart valves, blood vessels) molecular and microscopic processes determine their fate, so whether the implants ultimately fail or are successful.
    This course will introduce you to different classes of biomaterials and will show you which processes play a role at the molecular level at the biomaterial-tissue interface.

    Different subjects will be discussed which are listed below:
    1. History of biomaterials
    2. Classes of materials used in medicine; Polymers, Ceramics, Metals, Biopolymer
    3. The extracellular matrix; ECM-derived materials
    4. Biomaterial properties; Mechanical properties
    5. Biocompatibility & host reaction to biomaterials; In-vitro/in-vivo testing, Foreign Body Response - tissue response, Immune response, Inflammation, Wound healing, Complement system, Blood coagulation and blood-materials interactions, Biofilm formation and infections
    6. Processing of materials; Electro-spinning, FDM, Gelation/cryo-gelation, Surface patterning
    7. Protein-biomaterial interactions; Non-fouling surfaces
    8. Biomaterials for regenerative medicine/tissue engineering
    9. Cell/tissue-biomaterial interactions
    10. Bioactivation of biomaterials
    11. Self-assembled biomaterials; Supramolecular chemistry
    12. Implants and devices
    Entrance requirements
    You must have completed the final examination bsc program exam
    Entrance requirements tests
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    Assumed previous knowledge
    Basic tissue engineering, Basic knowledge of materials science (mechanical properties, polymers), of simple chemical structures, and of cell behavior in tissues.
    Previous knowledge can be gained by
    -
    Resources for self study
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    Required materials
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    Recommended materials
    Besides the book Biomaterials Science, by Ratner et al. Several scientific publications from recent literature will be discussed (will be posted on OASE).
    Articles covering recent literature.
    Biomaterials Science - An Introduction to Materials in Medicine by Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, Jack E. Lemons, Third Edition, Elsevier, 2013 (preferred)
    Instructional modes
    Lecture

    General
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    Remark
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    Tests
    Assignment
    Test weight15
    Minimum grade6
    Test typeInterim examination
    Number of opportunities1
    OpportunitiesBlock GS3
    Test duration in minutes-

    Assessment
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    Remark
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    Written examination
    Test weight85
    Minimum grade6
    Test typeFinal examination
    Number of opportunities2
    OpportunitiesBlock GS3, Block GS4
    Test duration in minutes-

    Assessment
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    Remark
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