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Course module: 8TC20
Basic tissue engineering
Course info
Course module8TC20
Credits (ECTS)5
Category3 (Advanced)
Course typeBachelor College
Language of instructionEnglish
Offered byEindhoven University of Technology; Biomedical Engineering; Orthopaedic Biomechanics;
Is part of
Biomedical Engineering
Pre-master program Biomedical Engineering
Coherent package - Tissue engineering
Medical Sciences and Engineering
Contact persondr. S. Hofmann Boss
prof.dr. D.L. Bader
Other course modules lecturer
Responsible lecturer
dr. S. Hofmann Boss
Other course modules lecturer
Contactperson for the course
dr. S. Hofmann Boss
Other course modules lecturer
prof.dr. K. Ito
Other course modules lecturer
Academic year2017
3  (05/02/2018 to 22/04/2018)
Starting block
TimeslotC: C - Tu 1-4, Fr 5-8, Fr 9-10
Course mode
Registration openfrom 15/11/2017 up to and including 07/01/2018
Application procedureYou apply via OSIRIS Student
Registration using OSIRISYes
Registration open for students from other department(s)Yes
Waiting listNo
Number of insufficient tests-
Number of groups of preference0
Learning objectives
After passing the course, the student:
  1. ... has insight in the multidisciplinary principles underpinning tissue engineering and can outline the conceptual strategies from various viewpoints.
  2. ... has insight into the scientific principles that underlie a series of repair strategies and can describe and apply these principles to specific tissues.
  3. ... can integrate his knowledge on tissue engineering by describing and reflecting on challenges associated with the tissue engineering industry and the translation to the clinics.
  4. ... can reflect on results typically obtained by tissue engineering experimental setups.
The course is centered on roughly five themes that concentrate on:

Introduction to tissue engineering:
  • Definitions
  • Historical/worldwide perspective
  • Industry
  • Regulatory affairs
Biomaterial scaffolds:
  • Bulk material vs scaffold
  • Limitations of existing biomaterials solutions
  • Highlighting the important medical needs
  • Choice of material, structure, processing methods incl. 3D printing
Cell biology, biochemistry and concepts of molecular biology:
  • Cell types, stem cells
  • Intracellular structures (membrane, cytoskeleton, nucleus)
  • Cell signaling (signaling molecules), cell growth and differentiation pathways
  • Cell culture and specific needs for different cell types
  • Growth factors
  • Mechanisms and control
  • Multi-cellular systems
  • Extracellular matrix, matrix molecules and their ligands
  • Controlled release strategies in tissue engineering
In vitro control of tissue development:
  • Concept of mechanotransduction
  • Physical characteristics for transplantation
  • Cell function in constructs
  • Influence of mechanical, chemical and extracellular matrix environment
  • Bioreactors for tissue engineered constructs (different uses: as training for tissues vs. for nutrient/metabolites transport vs for upscaling issues)
Construct Technology:
  • Models for tissue engineering, 2D vs 3D
  • Computational models
  • Assessment of function and quality of tissue engineering constructs (in vitro, in silico, in vivo, animal models)
  • Preservation of tissue engineered constructs
  • Organs-on-a-chip
  • Personalized medicine
Entrance requirements
Entrance requirements tests
Assumed previous knowledge
• 8TA00 - Cell and tissue (recommended)
• 8RB00 - Molecular cell biology (recommended )
Previous knowledge can be gained by
Resources for self study
Short promotional description of the course
Basis cursus tissue engineering, die bespreekt hoe cellen, scaffolds en technologie gecombineerd worden om levende implantaten te kweken.
Short promotional description of the course
Basic course in tissue engineering covering the central paradigm of cells, scaffolds and engineering methods to grow living replacement tissue.
Required materials
Recommended materials
Instructional modes
Guided selfstudy

Or guest lectures instead of independent learning.


Or guest lectures instead of lectures.

Written examination
Test weight100
Minimum grade-
Test typeFinal examination
Number of opportunities2
OpportunitiesBlock 3, Block 4
Test duration in minutes-



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